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Checklist Plug-and-play starting point Quality Assurance

Checklist: IND Application Content Completeness (21 CFR 312.23)

A plug-and-play checklist to confirm an Investigational New Drug application is complete before submission: forms, IB, protocol, CMC, pharmacology/toxicology, and prior human experience, mapped to 21 CFR 312.23, with a filled specimen.

Document type: Checklist

Read and copy the template below into your own quality system. It is a generic starting point for your own internal use, provided as is, with no warranty; see the Terms and License. Adopting it does not by itself create compliance.

This is a ready-to-use completeness checklist for an initial Investigational New Drug (IND) application, mapped to the content requirements in 21 CFR 312.23. It is a pre-submission gate: work each item to Yes, N/A with rationale, or a documented gap before the application goes to the FDA. Replace every <<FILL: ...>> placeholder. A filled specimen follows.

Checklist control

FieldEntry
Checklist number<<FILL: CHK-ID>>
Product / candidate<<FILL: candidate code, no confidential name>>
IND typeCommercial / Research / Expanded access / Emergency
Target submission date<<FILL>>
Completed by<<FILL>>

Section 1: Administrative and forms

#ItemRefStatus (Y / N / NA)Evidence / location
1.1Form FDA 1571 (cover sheet) complete and signed by the sponsor312.23(a)(1)<<FILL>><<FILL>>
1.2Form FDA 1572 (Statement of Investigator) for each clinical investigator312.23(a)(6), 312.53<<FILL>><<FILL>>
1.3Table of contents and correct eCTD structure312.23(a)(2)<<FILL>><<FILL>>
1.4Introductory statement and general investigational plan for the coming year312.23(a)(3)<<FILL>><<FILL>>

Section 2: Investigator’s Brochure and protocol

#ItemRefStatusEvidence / location
2.1Investigator’s Brochure per ICH E6, current and complete312.23(a)(5)<<FILL>><<FILL>>
2.2Reference safety information in the IB is defined and consistent312.23(a)(5)<<FILL>><<FILL>>
2.3Clinical protocol: objectives, design, population, dosing, endpoints312.23(a)(6)<<FILL>><<FILL>>
2.4Safety monitoring and explicit stopping rules stated312.23(a)(6)<<FILL>><<FILL>>
2.5IRB and informed-consent plans confirmed (Parts 56 and 50)312.23(a)(6), Part 50/56<<FILL>><<FILL>>
2.6Statistical considerations described312.23(a)(6)<<FILL>><<FILL>>

Section 3: Chemistry, Manufacturing, and Controls (Module 3)

#ItemRefStatusEvidence / location
3.1Drug substance: description, manufacture, control, characterization312.23(a)(7)<<FILL>><<FILL>>
3.2Drug product: composition, manufacture, control312.23(a)(7)<<FILL>><<FILL>>
3.3Specifications and analytical methods appropriate to phase312.23(a)(7)<<FILL>><<FILL>>
3.4Stability data covering the planned trial duration312.23(a)(7)<<FILL>><<FILL>>
3.5Labeling for investigational use (caution statement)312.23(a)(7), 312.6<<FILL>><<FILL>>
3.6Environmental assessment or claim of categorical exclusion312.23(a)(7)(iv)(e)<<FILL>><<FILL>>
3.7(Biologic) comparability plan flagged where process may changeICH Q5E<<FILL>><<FILL>>

Section 4: Pharmacology and toxicology (Module 4)

#ItemRefStatusEvidence / location
4.1Pharmacology and mechanism of action summarized312.23(a)(8)<<FILL>><<FILL>>
4.2GLP-compliant toxicology to the route and duration supporting the planned dosing312.23(a)(8), Part 58<<FILL>><<FILL>>
4.3Safety pharmacology and toxicokinetics as applicable312.23(a)(8), ICH S7/M3<<FILL>><<FILL>>
4.4First-in-human dose justification (NOAEL to human-equivalent dose, safety factor) documented and internally consistent312.23(a)(8)<<FILL>><<FILL>>
4.5GLP compliance statement or explanation of non-compliancePart 58<<FILL>><<FILL>>

Section 5: Previous human experience and other

#ItemRefStatusEvidence / location
5.1Previous human experience summarized (prior trials, foreign marketing)312.23(a)(9)<<FILL>><<FILL>>
5.2Any additional information (dependence, radioactive drugs) as applicable312.23(a)(10)<<FILL>><<FILL>>
5.3Pre-IND meeting held and agreements reflected in the submission312.47<<FILL>><<FILL>>

Sign-off

RoleNameSignatureDate
Regulatory lead<<FILL>>
CMC lead<<FILL>>
Nonclinical lead<<FILL>>
QA<<FILL>>

Filled specimen

Illustrative extract for a first-in-human commercial IND. Candidate and references are examples.

#ItemStatusEvidence / location
1.1Form FDA 1571 signedYm1/us/1571.pdf, signed 12 Jun 2026
4.2GLP 28-day repeat-dose tox in two speciesYm4/tox, studies TX-101, TX-102, GLP-compliant
4.4FIH dose justification: NOAEL 50 mg/kg, HED with 10x safety factor, start 3 levels below MRSDYIntroductory statement section 3; cross-checked to m4
3.4Stability: 6 months at 5 C and 25 C, covers 4-month trialYm3/3.2.P.8, ongoing
3.6Environmental: categorical exclusion claimedYm1 environmental claim
2.4Stopping rules at grade 2 or higher drug-related AEYProtocol section 6.4

Item 4.4 is the one reviewers scrutinize hardest for a first-in-human IND: if the dose-justification arithmetic in the introductory statement does not tie to the Module 4 toxicology, expect an information request that puts the 30-day clock under pressure.

Common gaps this checklist prevents

  • Dose-justification narrative that does not reconcile with the Module 4 NOAEL.
  • Stability data that does not cover the full planned trial duration.
  • Missing or unsigned Form 1572 for a named investigator.
  • Toxicology route or duration that does not support the proposed dosing.
  • Treating the 30-day period as an approval rather than a default-effective clock.

How to adapt this checklist

  1. Set the checklist number and candidate code in the control block.
  2. Add rows for modality-specific content (cell and gene therapy: vector, cell bank, potency; combination product: device-constituent and human factors).
  3. Point each evidence cell to the actual eCTD leaf location.
  4. Confirm the current regulation and ICH references before you rely on them; this is educational guidance, not regulatory advice.
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